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OBJECTIVE:To systematically evaluate the efficacy and safety of modified infusion(2-4 h infusion or continuous 24 h infusion)versus traditional infusion(0.5-1 h infusion)of meropenem in the treatment of severe infectious,and to provide evi-dence-based reference for clinic treatment. METHODS:Retrieved from Medline,CJFD,VIP database and Wanfang database, modified infusion(test group)versus traditional infusion(control group)of meropenem in the treatment of severe infections were collected,and Mata-analysis was performed by using Rev Man 5.0 statistical software after extracting data and evaluating quality. RESULTS:A total of 13 studies were included,involving 1 012 patients. Results of Meta-analysis showed the effective rate [RR=1.25,95%CI(1.10,1.43),P<0.001] and bacterial eradication rate [RR=1.25,95%CI(1.05,1.48),P=0.01] in test groups were sig-nificantly higher than those of control group,and there were no significant differences in the mortality rate [RR=0.74,95%CI (0.46,1.18),P=0.21] and incidence of adverse reactions [RR=0.81,95%CI(0.48,1.39),P=0.45]. CONCLUSIONS:Compared with traditional infusion of meropenem,extended or continuous infusion can improve efficacy in the treatment of severe infections, with similar safety. Due to methodology limit of included studies,large-scale and high quality RCT are required for further valida-tion of the conclusions.
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OBJECTIVE:To provide reference data for well understanding of high cost to access medical service for diabetic patients and controlling increase of medical costs.METHODS:Average daily cost of diabetic drugs in 1998 was compared with in 2008.At the same time it was compared with GDP and per-captia disposable income(PCDI).RESULTS:GDP,PCDI,consumption sum of total drugs and consumption sum of diabetic drugs in 2008 respectively were 3.78 times,3.11 times,3.87 times,2.73 times compared with in 1998.Amount of and daily average expenses of insulin respectively were 3.46 times,1.23 times;DDDs and daily average expense of oral hypoglycemics respectively were 1.69 times,1.41 times,compared with in 1998.Incremental rate of daily average expense of insulin injection and oral hypoglycemics were lower than that of PCDI.The daily average expense was increased as a result of the use of joint venture import drugs and new drugs and increase of diabetic patients.CONCLUSION:Incremental rate of daily average expense of diabetic drugs is lower than that of PCDI.High cost to access medical service for diabetic patients isn't equal to high cost of drugs.Many factors related should be considered from the point of view of society.
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OBJECTIVE: To probe into the status quo and the tendency of the application of intravenous infusions. METHODS: Data on the application of intravenous infusions in one of the tertiary Grade A comprehensive hospital in 1996, 1999, 2002 and 2004 were analyzed statistically. RESULTS: The variety of infusion, the total quantity and the total amount of money of infusions increased year by year,the total consumption sum of infusions accounted for 10% of that of the whole year drugs; the majority of which were the consumption of nutritional and dielectric medicines, of which, glucose and sodium chloride injections accounted for 74% of the total; the infusion of treatment type increased fast, much as in cases of anti - infec-tives; the drug expense for each bottle of infusion increased year by year, the amount of money involved in infusion drugs accounted for 60% of the total year round drug consumption sum. CONCLUSION: There is an upward trend in both the quantity and consumption sum of infusions.
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OBJECTIVE:To prepare psoralen liposome gel and to conduct a quan titative investigation about its drug re?lease model in vitro.METHODS:Taken psoralen liposome gel that of the same concentration as the control group,the model of drug release in vitro of the testing group was evaluated by dialyzing method and the stability of its drug release after storage for3weeks at4℃was studied as well.RESULTS:Compared with the control group,the testing group showed significant slow-releasing and long-acting effects and the drug release followed the Higuchi(k=4.67%h -1/2 )diffusion model in the first3hours and a zero order drug release model(k=0.74%h -1 )3hours later;The drug release of the control group followed the Higuchi(k=7.18%h -1/2 )diffusion model of within24hours;The drug release model and the envelop rates of the testing group remained stable within the storage date.CONCLUSION:This preparation is characterized by slow drug releasing in vitro and good stability.
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OBJECTIVE: To analyze the effect of bidding of antimicrobial drugs on hospital drugs consumption.METHODS: Based on the classification on drug bidding in 2007,the consumption data of antimicrobial drugs in 2006 in a 3-A grade hospital was analyzed,meanwhile,the price reduction rate,the consumption,the average daily cost and the impact factor of the antimicrobial drugs on the drug bidding list of 2007 were analyzed according to different specification or variety.RESULTS: The varieties winning the bid in 2007 which falls into the varieties winning the bid in 2006 represented 56.48% of all the varieties used in 2006,11 of the top 30 kinds of drugs in terms of consumption in 2006 also won the bid in 2007;accounting for 37.73% in consumption sum.In 2007 compared with 2006,cefamandole,cefodizime,pazufloxacin showed a biggest impact factor,whereas cefodizime and pazufloxacin ranked at the first 2 places in terms of weight impact factor.The proportion of the top 10 drugs in the total on the list of consumption sum remained steady from 2006 to 2007.CONCLUSIONS: The continuous drug bidding has positive meaning for patients,yet the benefit brought about by the drug price reduction is inconspicuous on account of the reduced consumption of the varieties which experienced drug reduction.Drug bidding remains to be improved because the average drug costs for patients haven't been brought down by the drug price reduction.